Fatty-acid synthesis — ACLY, ACC1, FASN (cytosolic teaching set)
Citrate exported from mitochondria is split to acetyl-CoA, carboxylated to malonyl-CoA, then assembled on FASN. One C2 cycle is drawn, not seven repeats and not bacterial type-II FAS.
ATP-citrate lyase ACLY
citrate + ATP + CoA → acetyl-CoA + OAA + ADP + Pi
Cleavage on 6UUW E599Q. Occupancy is ADP + CoA + Y2A (citryl-P analog) — not ATP, not citrate. No citryl-His on this mesh. Residue 599 is GLN.
EC 2.3.3.8 · PDB 6UUW
▶ OPEN SIMULATORAcetyl-CoA carboxylase 1 ACC1 · ACACA
HCO₃⁻ + acetyl-CoA + ATP → malonyl-CoA + ADP + Pi
Biotin carboxylase on 8XKZ. Occupancy is covalent BTN on Lys786 only — not ATP, not acetyl-CoA. Lys786 is the prosthetic biotin carrier. Citrate induced the filament (Regulation).
EC 6.4.1.2 · PDB 8XKZ
▶ OPEN SIMULATORFatty-acid synthase FASN
acetyl-CoA + 7 malonyl-CoA + 14 NADPH → palmitate
One C2 cycle on 8VF7 ACP@ER. Occupancy is 4HH (PPant-Ser2156) + NADPH — not acetyl, not malonyl, not palmitate. Cys161 / MAT Ser581 are named, not on this mesh.
EC 2.3.1.85 · PDB 8VF7
▶ OPEN SIMULATOR